Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma

Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by the uncontrolled proliferation of lymphocytes and histiocytes with hemophagocytic activity in the bone marrow. To our knowledge, there have been a few reported cases of pregnancy-related HLH. This case highli...

Descripción completa

Detalles Bibliográficos
Autores principales: Nasser, M. Farhan, Sharma, Shorabh, Albers, Elizabeth, Sharma, Sapna, Duggal, Anurag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959312/
https://www.ncbi.nlm.nih.gov/pubmed/29796364
http://dx.doi.org/10.7759/cureus.2352
_version_ 1783324369196417024
author Nasser, M. Farhan
Sharma, Shorabh
Albers, Elizabeth
Sharma, Sapna
Duggal, Anurag
author_facet Nasser, M. Farhan
Sharma, Shorabh
Albers, Elizabeth
Sharma, Sapna
Duggal, Anurag
author_sort Nasser, M. Farhan
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by the uncontrolled proliferation of lymphocytes and histiocytes with hemophagocytic activity in the bone marrow. To our knowledge, there have been a few reported cases of pregnancy-related HLH. This case highlights the importance of considering HLH in a pregnant woman along with other diagnoses, such as HELLP (which stands for hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome and hemolytic anemias. It points to the challenges of diagnosing and managing pregnancy-related HLH due to a similarity in presentation with other conditions.
format Online
Article
Text
id pubmed-5959312
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-59593122018-05-24 Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma Nasser, M. Farhan Sharma, Shorabh Albers, Elizabeth Sharma, Sapna Duggal, Anurag Cureus Internal Medicine Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by the uncontrolled proliferation of lymphocytes and histiocytes with hemophagocytic activity in the bone marrow. To our knowledge, there have been a few reported cases of pregnancy-related HLH. This case highlights the importance of considering HLH in a pregnant woman along with other diagnoses, such as HELLP (which stands for hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome and hemolytic anemias. It points to the challenges of diagnosing and managing pregnancy-related HLH due to a similarity in presentation with other conditions. Cureus 2018-03-20 /pmc/articles/PMC5959312/ /pubmed/29796364 http://dx.doi.org/10.7759/cureus.2352 Text en Copyright © 2018, Nasser et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Nasser, M. Farhan
Sharma, Shorabh
Albers, Elizabeth
Sharma, Sapna
Duggal, Anurag
Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title_full Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title_fullStr Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title_full_unstemmed Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title_short Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma
title_sort pregnancy-related hemophagocytic lymphohistiocytosis associated with herpes simplex virus-2 infection: a diagnostic dilemma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959312/
https://www.ncbi.nlm.nih.gov/pubmed/29796364
http://dx.doi.org/10.7759/cureus.2352
work_keys_str_mv AT nassermfarhan pregnancyrelatedhemophagocyticlymphohistiocytosisassociatedwithherpessimplexvirus2infectionadiagnosticdilemma
AT sharmashorabh pregnancyrelatedhemophagocyticlymphohistiocytosisassociatedwithherpessimplexvirus2infectionadiagnosticdilemma
AT alberselizabeth pregnancyrelatedhemophagocyticlymphohistiocytosisassociatedwithherpessimplexvirus2infectionadiagnosticdilemma
AT sharmasapna pregnancyrelatedhemophagocyticlymphohistiocytosisassociatedwithherpessimplexvirus2infectionadiagnosticdilemma
AT duggalanurag pregnancyrelatedhemophagocyticlymphohistiocytosisassociatedwithherpessimplexvirus2infectionadiagnosticdilemma

Ejemplares similares