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Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is poorly understood despite its potential impact on driving broadly protective immu...

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Detalles Bibliográficos
Autores principales:	Burton, Bronwen R, Tennant, Richard K, Love, John, Titball, Richard W, Wraith, David C, White, Harry N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959717/ https://www.ncbi.nlm.nih.gov/pubmed/29709214 http://dx.doi.org/10.7554/eLife.26832

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