Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis

BACKGROUND: There is substantial evidence that signaling through Toll-like receptor 4 (TLR4) contributes to the pathogenesis of necrotizing enterocolitis (NEC). Pregnane X receptor (PXR), a xenobiotic sensor and signaling intermediate for certain host-bacterial metabolites, has been shown to negativ...

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Detalles Bibliográficos
Autores principales: Huang, Kezhen, Mukherjee, Subhajit, DesMarais, Vera, Albanese, Joseph M., Rafti, Ektor, Draghi, Andrew, Maher, Leigh A., Khanna, Kamal M., Mani, Sridhar, Matson, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959752/
https://www.ncbi.nlm.nih.gov/pubmed/29360809
http://dx.doi.org/10.1038/pr.2018.14

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