Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Effective treatment for glioblastoma (GBM) is limited by the presence of the blood–brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. Using intravital...

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Detalles Bibliográficos
Autores principales: Lam, Fred C., Morton, Stephen W., Wyckoff, Jeffrey, Vu Han, Tu-Lan, Hwang, Mun Kyung, Maffa, Amanda, Balkanska-Sinclair, Elena, Yaffe, Michael B, Floyd, Scott R, Hammond, Paula T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959860/
https://www.ncbi.nlm.nih.gov/pubmed/29777137
http://dx.doi.org/10.1038/s41467-018-04315-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959860/
https://www.ncbi.nlm.nih.gov/pubmed/29777137
http://dx.doi.org/10.1038/s41467-018-04315-4

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