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Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter
Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959884/ https://www.ncbi.nlm.nih.gov/pubmed/29777191 http://dx.doi.org/10.1038/s41598-018-26293-9 |
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author | Shimizu, Kohei Soroida, Yoko Sato, Masaya Hikita, Hiromi Kobayashi, Tamaki Endo, Momoe Sato, Mamiko Gotoh, Hiroaki Iwai, Tomomi Tateishi, Ryosuke Koike, Kazuhiko Yatomi, Yutaka Ikeda, Hitoshi |
author_facet | Shimizu, Kohei Soroida, Yoko Sato, Masaya Hikita, Hiromi Kobayashi, Tamaki Endo, Momoe Sato, Mamiko Gotoh, Hiroaki Iwai, Tomomi Tateishi, Ryosuke Koike, Kazuhiko Yatomi, Yutaka Ikeda, Hitoshi |
author_sort | Shimizu, Kohei |
collection | PubMed |
description | Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA). We then evaluated the state of hepatic steatosis before and after HCV eradication. We also investigated the changes in serum parameters such as cholesterol and glucose levels. The median value of CAP level decreased significantly after HCV eradication from 273 dB/m to 265 dB/m (P = 0.034). Also, LDL and HDL cholesterol levels increased significantly after HCV eradication (P = 0.002 and P = 0.027, respectively). In conclusion, a decrease in hepatic steatosis after HCV eradication with DAA was revealed in chronic hepatitis C patients with significant steatosis. Cancellation of the viral effect is a possible underlying cause of hepatic steatosis improvement and increase in HDL and LDL cholesterol levels. |
format | Online Article Text |
id | pubmed-5959884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59598842018-05-24 Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter Shimizu, Kohei Soroida, Yoko Sato, Masaya Hikita, Hiromi Kobayashi, Tamaki Endo, Momoe Sato, Mamiko Gotoh, Hiroaki Iwai, Tomomi Tateishi, Ryosuke Koike, Kazuhiko Yatomi, Yutaka Ikeda, Hitoshi Sci Rep Article Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA). We then evaluated the state of hepatic steatosis before and after HCV eradication. We also investigated the changes in serum parameters such as cholesterol and glucose levels. The median value of CAP level decreased significantly after HCV eradication from 273 dB/m to 265 dB/m (P = 0.034). Also, LDL and HDL cholesterol levels increased significantly after HCV eradication (P = 0.002 and P = 0.027, respectively). In conclusion, a decrease in hepatic steatosis after HCV eradication with DAA was revealed in chronic hepatitis C patients with significant steatosis. Cancellation of the viral effect is a possible underlying cause of hepatic steatosis improvement and increase in HDL and LDL cholesterol levels. Nature Publishing Group UK 2018-05-18 /pmc/articles/PMC5959884/ /pubmed/29777191 http://dx.doi.org/10.1038/s41598-018-26293-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shimizu, Kohei Soroida, Yoko Sato, Masaya Hikita, Hiromi Kobayashi, Tamaki Endo, Momoe Sato, Mamiko Gotoh, Hiroaki Iwai, Tomomi Tateishi, Ryosuke Koike, Kazuhiko Yatomi, Yutaka Ikeda, Hitoshi Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title | Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title_full | Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title_fullStr | Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title_full_unstemmed | Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title_short | Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
title_sort | eradication of hepatitis c virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959884/ https://www.ncbi.nlm.nih.gov/pubmed/29777191 http://dx.doi.org/10.1038/s41598-018-26293-9 |
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