Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition

BACKGROUND: Cancer-associated fibroblasts (CAFs) support tumour progression and invasion, and they secrete abundant extracellular matrix (ECM) that may shield tumour cells from immune checkpoint or kinase inhibitors. Targeting CAFs using drugs that revert their differentiation, or inhibit their tumo...

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Detalles Bibliográficos
Autores principales: Kim, Dae Joong, Dunleavey, James M., Xiao, Lin, Ollila, David W., Troester, Melissa A., Otey, Carol A., Li, Wei, Barker, Thomas H., Dudley, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959903/
https://www.ncbi.nlm.nih.gov/pubmed/29695769
http://dx.doi.org/10.1038/s41416-018-0072-3

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