A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine

BACKGROUND: Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed a...

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Detalles Bibliográficos
Autores principales: Herfs, Michael, Roncarati, Patrick, Koopmansch, Benjamin, Peulen, Olivier, Bruyere, Diane, Lebeau, Alizee, Hendrick, Elodie, Hubert, Pascale, Poncin, Aurelie, Penny, William, Piazzon, Nathalie, Monnien, Franck, Guenat, David, Mougin, Christiane, Prétet, Jean-Luc, Vuitton, Lucine, Segers, Karin, Lambert, Frederic, Bours, Vincent, de Leval, Laurence, Valmary-Degano, Severine, Quick, Charles M, Crum, Christopher P, Delvenne, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959925/
https://www.ncbi.nlm.nih.gov/pubmed/29700411
http://dx.doi.org/10.1038/s41416-018-0049-2

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