Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells

The development of metabolic oligosaccharide engineering (MOE) over the past two decades enabled the bioimaging studies of glycosylation processes in physio-pathological contexts. Herein, we successfully applied the chemical reporter strategy to image the fate of sialylated glycoconjugates in health...

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Autores principales: Gilormini, Pierre André, Lion, Cédric, Vicogne, Dorothée, Guérardel, Yann, Foulquier, François, Biot, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Glycomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959963/
https://www.ncbi.nlm.nih.gov/pubmed/29294191
http://dx.doi.org/10.1007/s10545-017-0118-3
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author Gilormini, Pierre André
Lion, Cédric
Vicogne, Dorothée
Guérardel, Yann
Foulquier, François
Biot, Christophe
author_facet Gilormini, Pierre André
Lion, Cédric
Vicogne, Dorothée
Guérardel, Yann
Foulquier, François
Biot, Christophe
author_sort Gilormini, Pierre André
collection PubMed
description The development of metabolic oligosaccharide engineering (MOE) over the past two decades enabled the bioimaging studies of glycosylation processes in physio-pathological contexts. Herein, we successfully applied the chemical reporter strategy to image the fate of sialylated glycoconjugates in healthy and sialin-deficient patient fibroblasts. This chemical glycomics enrichment is a powerful tool for tracking sialylated glycoconjugates and probing lysosomal recycling capacities. Thus, such strategies appear fundamental for the characterization of lysosomal storage diseases.
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spelling pubmed-59599632018-05-24 Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells Gilormini, Pierre André Lion, Cédric Vicogne, Dorothée Guérardel, Yann Foulquier, François Biot, Christophe J Inherit Metab Dis Glycomics The development of metabolic oligosaccharide engineering (MOE) over the past two decades enabled the bioimaging studies of glycosylation processes in physio-pathological contexts. Herein, we successfully applied the chemical reporter strategy to image the fate of sialylated glycoconjugates in healthy and sialin-deficient patient fibroblasts. This chemical glycomics enrichment is a powerful tool for tracking sialylated glycoconjugates and probing lysosomal recycling capacities. Thus, such strategies appear fundamental for the characterization of lysosomal storage diseases. Springer Netherlands 2018-01-02 2018 /pmc/articles/PMC5959963/ /pubmed/29294191 http://dx.doi.org/10.1007/s10545-017-0118-3 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Glycomics
Gilormini, Pierre André
Lion, Cédric
Vicogne, Dorothée
Guérardel, Yann
Foulquier, François
Biot, Christophe
Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title_full Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title_fullStr Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title_full_unstemmed Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title_short Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
title_sort chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
topic Glycomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959963/
https://www.ncbi.nlm.nih.gov/pubmed/29294191
http://dx.doi.org/10.1007/s10545-017-0118-3
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