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Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

BACKGROUND: Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neuroprotectiv...

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Detalles Bibliográficos
Autores principales:	Gao, Bo, Wu, Yu, Yang, Yuan-Jian, Li, Wei-Zu, Dong, Kun, Zhou, Jun, Yin, Yan-Yan, Huang, Da-Ke, Wu, Wen-Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960124/ https://www.ncbi.nlm.nih.gov/pubmed/29776417 http://dx.doi.org/10.1186/s12974-018-1199-0

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