Neutrophils in traumatic brain injury (TBI): friend or foe?

Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonethe...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yang-Wuyue, Li, Song, Dai, Shuang-Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960133/
https://www.ncbi.nlm.nih.gov/pubmed/29776443
http://dx.doi.org/10.1186/s12974-018-1173-x
_version_ 1783324531761348608
author Liu, Yang-Wuyue
Li, Song
Dai, Shuang-Shuang
author_facet Liu, Yang-Wuyue
Li, Song
Dai, Shuang-Shuang
author_sort Liu, Yang-Wuyue
collection PubMed
description Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.
format Online
Article
Text
id pubmed-5960133
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-59601332018-05-24 Neutrophils in traumatic brain injury (TBI): friend or foe? Liu, Yang-Wuyue Li, Song Dai, Shuang-Shuang J Neuroinflammation Review Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI. BioMed Central 2018-05-17 /pmc/articles/PMC5960133/ /pubmed/29776443 http://dx.doi.org/10.1186/s12974-018-1173-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Liu, Yang-Wuyue
Li, Song
Dai, Shuang-Shuang
Neutrophils in traumatic brain injury (TBI): friend or foe?
title Neutrophils in traumatic brain injury (TBI): friend or foe?
title_full Neutrophils in traumatic brain injury (TBI): friend or foe?
title_fullStr Neutrophils in traumatic brain injury (TBI): friend or foe?
title_full_unstemmed Neutrophils in traumatic brain injury (TBI): friend or foe?
title_short Neutrophils in traumatic brain injury (TBI): friend or foe?
title_sort neutrophils in traumatic brain injury (tbi): friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960133/
https://www.ncbi.nlm.nih.gov/pubmed/29776443
http://dx.doi.org/10.1186/s12974-018-1173-x
work_keys_str_mv AT liuyangwuyue neutrophilsintraumaticbraininjurytbifriendorfoe
AT lisong neutrophilsintraumaticbraininjurytbifriendorfoe
AT daishuangshuang neutrophilsintraumaticbraininjurytbifriendorfoe

Ejemplares similares