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Neutrophils in traumatic brain injury (TBI): friend or foe?
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonethe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960133/ https://www.ncbi.nlm.nih.gov/pubmed/29776443 http://dx.doi.org/10.1186/s12974-018-1173-x |
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author | Liu, Yang-Wuyue Li, Song Dai, Shuang-Shuang |
author_facet | Liu, Yang-Wuyue Li, Song Dai, Shuang-Shuang |
author_sort | Liu, Yang-Wuyue |
collection | PubMed |
description | Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI. |
format | Online Article Text |
id | pubmed-5960133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59601332018-05-24 Neutrophils in traumatic brain injury (TBI): friend or foe? Liu, Yang-Wuyue Li, Song Dai, Shuang-Shuang J Neuroinflammation Review Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI. BioMed Central 2018-05-17 /pmc/articles/PMC5960133/ /pubmed/29776443 http://dx.doi.org/10.1186/s12974-018-1173-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Liu, Yang-Wuyue Li, Song Dai, Shuang-Shuang Neutrophils in traumatic brain injury (TBI): friend or foe? |
title | Neutrophils in traumatic brain injury (TBI): friend or foe? |
title_full | Neutrophils in traumatic brain injury (TBI): friend or foe? |
title_fullStr | Neutrophils in traumatic brain injury (TBI): friend or foe? |
title_full_unstemmed | Neutrophils in traumatic brain injury (TBI): friend or foe? |
title_short | Neutrophils in traumatic brain injury (TBI): friend or foe? |
title_sort | neutrophils in traumatic brain injury (tbi): friend or foe? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960133/ https://www.ncbi.nlm.nih.gov/pubmed/29776443 http://dx.doi.org/10.1186/s12974-018-1173-x |
work_keys_str_mv | AT liuyangwuyue neutrophilsintraumaticbraininjurytbifriendorfoe AT lisong neutrophilsintraumaticbraininjurytbifriendorfoe AT daishuangshuang neutrophilsintraumaticbraininjurytbifriendorfoe |