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Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons

BACKGROUND: 3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for the production of steroidal pharmaceutical intermediates. Three KstDs, KstD1, Kst...

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Detalles Bibliográficos
Autores principales:	Zhang, Ruijie, Liu, Xiangcen, Wang, Yushi, Han, Yuchang, Sun, Junsong, Shi, Jiping, Zhang, Baoguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960168/ https://www.ncbi.nlm.nih.gov/pubmed/29776364 http://dx.doi.org/10.1186/s12934-018-0916-9

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