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Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
BACKGROUND: Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting interest in whether the accumulation of a misfolded protein in pathologic featur...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960184/ https://www.ncbi.nlm.nih.gov/pubmed/29776378 http://dx.doi.org/10.1186/s13024-018-0253-9 |