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Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype
BACKGROUND: Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960198/ https://www.ncbi.nlm.nih.gov/pubmed/29776403 http://dx.doi.org/10.1186/s12917-018-1483-3 |
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author | Sokołowski, Wojciech Czubaj, Norbert Skibniewski, Michał Barszcz, Karolina Kupczyńska, Marta Kinda, Wojciech Kiełbowicz, Zdzisław |
author_facet | Sokołowski, Wojciech Czubaj, Norbert Skibniewski, Michał Barszcz, Karolina Kupczyńska, Marta Kinda, Wojciech Kiełbowicz, Zdzisław |
author_sort | Sokołowski, Wojciech |
collection | PubMed |
description | BACKGROUND: Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebrospinal fluid (CSF) drainage, the RCF has not been studied extensively. Literature reports indicate that a decreased caudal cranial fossa (CCF) volume in the course of the Chiari-like malformation may obstruct CSF circulation. We hypothesised that morphological diversity among different breeds in the volume of the RCF may affect CSF circulation. The aim of the study was to carry out a volumetric analysis of the RCF and the cranial cavity and to determine the ratio between them in dog breeds of different size and morphotype. We performed computed tomography (CT) morphometric analysis of the RCF compartment by obtaining volume measurements from the transverse and reformatted sagittal and dorsal planes. RESULTS: The rostral cranial fossa percentage – volume of the rostral cranial fossa/volume of cranial cavity × 100 (volRCF/volCC × 100) was lower in small and brachycephalic dog breeds than in the other dogs. CONCLUSIONS: A reduced RCF volume was detected in small and brachycephalic dog breeds, some of which are predisposed to congenital hydrocephalus. This may lead to overcrowding of brain parenchyma in the RCF and may impede CSF circulation. Our observations may be useful for future studies focusing on the causes and new therapies to treat conditions such as hydrocephalus and syringomyelia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-018-1483-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5960198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59601982018-05-24 Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype Sokołowski, Wojciech Czubaj, Norbert Skibniewski, Michał Barszcz, Karolina Kupczyńska, Marta Kinda, Wojciech Kiełbowicz, Zdzisław BMC Vet Res Research Article BACKGROUND: Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebrospinal fluid (CSF) drainage, the RCF has not been studied extensively. Literature reports indicate that a decreased caudal cranial fossa (CCF) volume in the course of the Chiari-like malformation may obstruct CSF circulation. We hypothesised that morphological diversity among different breeds in the volume of the RCF may affect CSF circulation. The aim of the study was to carry out a volumetric analysis of the RCF and the cranial cavity and to determine the ratio between them in dog breeds of different size and morphotype. We performed computed tomography (CT) morphometric analysis of the RCF compartment by obtaining volume measurements from the transverse and reformatted sagittal and dorsal planes. RESULTS: The rostral cranial fossa percentage – volume of the rostral cranial fossa/volume of cranial cavity × 100 (volRCF/volCC × 100) was lower in small and brachycephalic dog breeds than in the other dogs. CONCLUSIONS: A reduced RCF volume was detected in small and brachycephalic dog breeds, some of which are predisposed to congenital hydrocephalus. This may lead to overcrowding of brain parenchyma in the RCF and may impede CSF circulation. Our observations may be useful for future studies focusing on the causes and new therapies to treat conditions such as hydrocephalus and syringomyelia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-018-1483-3) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-18 /pmc/articles/PMC5960198/ /pubmed/29776403 http://dx.doi.org/10.1186/s12917-018-1483-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sokołowski, Wojciech Czubaj, Norbert Skibniewski, Michał Barszcz, Karolina Kupczyńska, Marta Kinda, Wojciech Kiełbowicz, Zdzisław Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title | Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title_full | Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title_fullStr | Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title_full_unstemmed | Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title_short | Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
title_sort | rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960198/ https://www.ncbi.nlm.nih.gov/pubmed/29776403 http://dx.doi.org/10.1186/s12917-018-1483-3 |
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