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The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

BACKGROUND: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for ant...

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Detalles Bibliográficos
Autores principales:	Berning, Philipp, Schaefer, Christiane, Clemens, Dagmar, Korsching, Eberhard, Dirksen, Uta, Potratz, Jenny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960216/ https://www.ncbi.nlm.nih.gov/pubmed/29776413 http://dx.doi.org/10.1186/s12964-018-0233-2

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