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Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols

BACKGROUND: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma...

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Autores principales: Serrano Mujica, Lady, Bridi, Alessandra, Della Méa, Ricardo, Rissi, Vitor Braga, Guarda, Naiara, Moresco, Rafael Noal, Premaor, Melissa Orlandin, Antoniazzi, Alfredo Quites, Gonçalves, Paulo Bayard Dias, Comim, Fabio Vasconcellos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960249/
https://www.ncbi.nlm.nih.gov/pubmed/29805266
http://dx.doi.org/10.2147/JIR.S160264
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author Serrano Mujica, Lady
Bridi, Alessandra
Della Méa, Ricardo
Rissi, Vitor Braga
Guarda, Naiara
Moresco, Rafael Noal
Premaor, Melissa Orlandin
Antoniazzi, Alfredo Quites
Gonçalves, Paulo Bayard Dias
Comim, Fabio Vasconcellos
author_facet Serrano Mujica, Lady
Bridi, Alessandra
Della Méa, Ricardo
Rissi, Vitor Braga
Guarda, Naiara
Moresco, Rafael Noal
Premaor, Melissa Orlandin
Antoniazzi, Alfredo Quites
Gonçalves, Paulo Bayard Dias
Comim, Fabio Vasconcellos
author_sort Serrano Mujica, Lady
collection PubMed
description BACKGROUND: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma oxidative stress marker and metabolic parameter characteristics of prenatal (PreN) and postnatal (PostN) androgenized rat models of PCOS. MATERIALS AND METHODS: For PreN androgenization (n=8), 2.5 mg of testosterone propionate was subcutaneously administered to dams at embryonic days 16, 17, and 18, whereas PostN androgenization (n=7) was accomplished by subcutaneously injecting 1.25 mg of testosterone propionate to animals at PostN day 5. A unique control group (n=8) was constituted for comparison. RESULTS: Our results indicate that PostN group rats exhibited particular modifications in the oxidative stress marker, an increased plasma ferric-reducing ability of plasma, and an increased antioxidant capacity reflected by higher albumin serum levels. PostN animals also presented increased total cholesterol and triglyceride–glucose levels, suggesting severe metabolic disarrangement. CONCLUSION: Study findings indicate that changes in oxidative stress could be promoted by testosterone propionate exposure after birth, which is likely associated with anovulation and/or lipid disarrangement.
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spelling pubmed-59602492018-05-25 Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols Serrano Mujica, Lady Bridi, Alessandra Della Méa, Ricardo Rissi, Vitor Braga Guarda, Naiara Moresco, Rafael Noal Premaor, Melissa Orlandin Antoniazzi, Alfredo Quites Gonçalves, Paulo Bayard Dias Comim, Fabio Vasconcellos J Inflamm Res Original Research BACKGROUND: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma oxidative stress marker and metabolic parameter characteristics of prenatal (PreN) and postnatal (PostN) androgenized rat models of PCOS. MATERIALS AND METHODS: For PreN androgenization (n=8), 2.5 mg of testosterone propionate was subcutaneously administered to dams at embryonic days 16, 17, and 18, whereas PostN androgenization (n=7) was accomplished by subcutaneously injecting 1.25 mg of testosterone propionate to animals at PostN day 5. A unique control group (n=8) was constituted for comparison. RESULTS: Our results indicate that PostN group rats exhibited particular modifications in the oxidative stress marker, an increased plasma ferric-reducing ability of plasma, and an increased antioxidant capacity reflected by higher albumin serum levels. PostN animals also presented increased total cholesterol and triglyceride–glucose levels, suggesting severe metabolic disarrangement. CONCLUSION: Study findings indicate that changes in oxidative stress could be promoted by testosterone propionate exposure after birth, which is likely associated with anovulation and/or lipid disarrangement. Dove Medical Press 2018-05-15 /pmc/articles/PMC5960249/ /pubmed/29805266 http://dx.doi.org/10.2147/JIR.S160264 Text en © 2018 Serrano Mujica et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Serrano Mujica, Lady
Bridi, Alessandra
Della Méa, Ricardo
Rissi, Vitor Braga
Guarda, Naiara
Moresco, Rafael Noal
Premaor, Melissa Orlandin
Antoniazzi, Alfredo Quites
Gonçalves, Paulo Bayard Dias
Comim, Fabio Vasconcellos
Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_full Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_fullStr Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_full_unstemmed Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_short Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_sort oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960249/
https://www.ncbi.nlm.nih.gov/pubmed/29805266
http://dx.doi.org/10.2147/JIR.S160264
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