Cargando…
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl(−)/water secretion that involves cAMP-dependent activation of CFTR
Constipation is a common symptom frequently compromising the quality of daily life. Several mechanistically different drugs have been used to mitigate constipation, including Japanese herbal (Kampo) medicines. However, the mechanisms of their actions are often not well understood. Here we aimed to i...
Autores principales: | Numata, Tomohiro, Sato-Numata, Kaori, Okada, Yasunobu, Inoue, Ryuji |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960480/ https://www.ncbi.nlm.nih.gov/pubmed/29569221 http://dx.doi.org/10.1007/s11418-018-1207-9 |
Ejemplares similares
-
Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels
por: Numata, Tomohiro, et al.
Publicado: (2019) -
Distinct contributions of LRRC8A and its paralogs to the VSOR anion channel from those of the ASOR anion channel
por: Sato-Numata, Kaori, et al.
Publicado: (2016) -
TRPM7 is involved in acid‐induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells
por: Numata, Tomohiro, et al.
Publicado: (2019) -
Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 2: Functional and Molecular Properties of ASOR/PAC Channels and Their Roles in Cell Volume Dysregulation and Acidotoxic Cell Death
por: Okada, Yasunobu, et al.
Publicado: (2021) -
Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death
por: Okada, Yasunobu, et al.
Publicado: (2021)