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A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma

In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the act...

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Autores principales: Katsanos, Andreas, Konstas, Anastasios G., Mikropoulos, Dimitrios G., Quaranta, Luciano, Voudouragkaki, Irini C., Athanasopoulos, Georgios P., Asproudis, Ioannis, Teus, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960484/
https://www.ncbi.nlm.nih.gov/pubmed/29644538
http://dx.doi.org/10.1007/s12325-018-0695-z
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author Katsanos, Andreas
Konstas, Anastasios G.
Mikropoulos, Dimitrios G.
Quaranta, Luciano
Voudouragkaki, Irini C.
Athanasopoulos, Georgios P.
Asproudis, Ioannis
Teus, Miguel A.
author_facet Katsanos, Andreas
Konstas, Anastasios G.
Mikropoulos, Dimitrios G.
Quaranta, Luciano
Voudouragkaki, Irini C.
Athanasopoulos, Georgios P.
Asproudis, Ioannis
Teus, Miguel A.
author_sort Katsanos, Andreas
collection PubMed
description In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. SLT's non-disruptive mode of action offers the advantage of repeatability. Exfoliation glaucoma (XFG) is a secondary open-angle glaucoma with unfavorable intraocular pressure (IOP) characteristics, which typically carries a poorer long-term prognosis than primary open-angle glaucoma. Consequently, patients with XFG often need multiple medications to achieve IOP levels that prevent disease progression. Because complicated pharmacotherapy regimens undermine the long-term tolerability and compliance of patients with XFG, options such as SLT may decrease the burden of multiple therapies and ultimately improve prognosis. In fact, SLT may be a particularly attractive option in XFG because the pigment-laden trabecular tissue of these patients enhances the absorption of laser energy and thus augments the biologic effects induced by this treatment. The current article reviews the postulated mechanisms of action of SLT, discusses practical aspects of SLT therapy, and examines selected peer-reviewed literature pertaining to the clinical usefulness of this modality in XFG patients.
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spelling pubmed-59604842018-05-25 A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma Katsanos, Andreas Konstas, Anastasios G. Mikropoulos, Dimitrios G. Quaranta, Luciano Voudouragkaki, Irini C. Athanasopoulos, Georgios P. Asproudis, Ioannis Teus, Miguel A. Adv Ther Review In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. SLT's non-disruptive mode of action offers the advantage of repeatability. Exfoliation glaucoma (XFG) is a secondary open-angle glaucoma with unfavorable intraocular pressure (IOP) characteristics, which typically carries a poorer long-term prognosis than primary open-angle glaucoma. Consequently, patients with XFG often need multiple medications to achieve IOP levels that prevent disease progression. Because complicated pharmacotherapy regimens undermine the long-term tolerability and compliance of patients with XFG, options such as SLT may decrease the burden of multiple therapies and ultimately improve prognosis. In fact, SLT may be a particularly attractive option in XFG because the pigment-laden trabecular tissue of these patients enhances the absorption of laser energy and thus augments the biologic effects induced by this treatment. The current article reviews the postulated mechanisms of action of SLT, discusses practical aspects of SLT therapy, and examines selected peer-reviewed literature pertaining to the clinical usefulness of this modality in XFG patients. Springer Healthcare 2018-04-11 2018 /pmc/articles/PMC5960484/ /pubmed/29644538 http://dx.doi.org/10.1007/s12325-018-0695-z Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Katsanos, Andreas
Konstas, Anastasios G.
Mikropoulos, Dimitrios G.
Quaranta, Luciano
Voudouragkaki, Irini C.
Athanasopoulos, Georgios P.
Asproudis, Ioannis
Teus, Miguel A.
A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title_full A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title_fullStr A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title_full_unstemmed A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title_short A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma
title_sort review of the clinical usefulness of selective laser trabeculoplasty in exfoliative glaucoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960484/
https://www.ncbi.nlm.nih.gov/pubmed/29644538
http://dx.doi.org/10.1007/s12325-018-0695-z
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