Prospects of IL-2 in Cancer Immunotherapy

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer pa...

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Detalles Bibliográficos
Autores principales: Choudhry, Hani, Helmi, Nawal, Abdulaal, Wesam H., Zeyadi, Mustafa, Zamzami, Mazin A., Wu, Wei, Mahmoud, Maged Mostafa, Warsi, Mohiuddin Khan, Rasool, Mahmood, Jamal, Mohammad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960517/
https://www.ncbi.nlm.nih.gov/pubmed/29854806
http://dx.doi.org/10.1155/2018/9056173
Descripción
Sumario:IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.

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