Prospects of IL-2 in Cancer Immunotherapy

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer pa...

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Autores principales: Choudhry, Hani, Helmi, Nawal, Abdulaal, Wesam H., Zeyadi, Mustafa, Zamzami, Mazin A., Wu, Wei, Mahmoud, Maged Mostafa, Warsi, Mohiuddin Khan, Rasool, Mahmood, Jamal, Mohammad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960517/
https://www.ncbi.nlm.nih.gov/pubmed/29854806
http://dx.doi.org/10.1155/2018/9056173
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author Choudhry, Hani
Helmi, Nawal
Abdulaal, Wesam H.
Zeyadi, Mustafa
Zamzami, Mazin A.
Wu, Wei
Mahmoud, Maged Mostafa
Warsi, Mohiuddin Khan
Rasool, Mahmood
Jamal, Mohammad S.
author_facet Choudhry, Hani
Helmi, Nawal
Abdulaal, Wesam H.
Zeyadi, Mustafa
Zamzami, Mazin A.
Wu, Wei
Mahmoud, Maged Mostafa
Warsi, Mohiuddin Khan
Rasool, Mahmood
Jamal, Mohammad S.
author_sort Choudhry, Hani
collection PubMed
description IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.
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spelling pubmed-59605172018-05-31 Prospects of IL-2 in Cancer Immunotherapy Choudhry, Hani Helmi, Nawal Abdulaal, Wesam H. Zeyadi, Mustafa Zamzami, Mazin A. Wu, Wei Mahmoud, Maged Mostafa Warsi, Mohiuddin Khan Rasool, Mahmood Jamal, Mohammad S. Biomed Res Int Review Article IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer. Hindawi 2018-05-06 /pmc/articles/PMC5960517/ /pubmed/29854806 http://dx.doi.org/10.1155/2018/9056173 Text en Copyright © 2018 Hani Choudhry et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choudhry, Hani
Helmi, Nawal
Abdulaal, Wesam H.
Zeyadi, Mustafa
Zamzami, Mazin A.
Wu, Wei
Mahmoud, Maged Mostafa
Warsi, Mohiuddin Khan
Rasool, Mahmood
Jamal, Mohammad S.
Prospects of IL-2 in Cancer Immunotherapy
title Prospects of IL-2 in Cancer Immunotherapy
title_full Prospects of IL-2 in Cancer Immunotherapy
title_fullStr Prospects of IL-2 in Cancer Immunotherapy
title_full_unstemmed Prospects of IL-2 in Cancer Immunotherapy
title_short Prospects of IL-2 in Cancer Immunotherapy
title_sort prospects of il-2 in cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960517/
https://www.ncbi.nlm.nih.gov/pubmed/29854806
http://dx.doi.org/10.1155/2018/9056173
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