March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of MHC class II and CD86 in T cell activation and to get further insights in...

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Detalles Bibliográficos
Autores principales: Kishta, Osama A., Sabourin, Antoine, Simon, Leora, McGovern, Toby, Raymond, Maxime, Galbas, Tristan, Majdoubi, Abdelilah, Ishido, Satoshi, Martin, James G., Thibodeau, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960577/
https://www.ncbi.nlm.nih.gov/pubmed/29854835
http://dx.doi.org/10.1155/2018/3823910

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