A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation

Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation, neurodevelopment, aging and synaptic function. In addition to the control of Ca(2+) currents, IGF-1R signaling modulates the activity of calcium-calmoduli...

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Detalles Bibliográficos
Autores principales: Ogundele, Olalekan M., Pardo, Joaquin, Francis, Joseph, Goya, Rodolfo G., Lee, Charles C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960681/
https://www.ncbi.nlm.nih.gov/pubmed/29867375
http://dx.doi.org/10.3389/fnana.2018.00035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960681/
https://www.ncbi.nlm.nih.gov/pubmed/29867375
http://dx.doi.org/10.3389/fnana.2018.00035

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