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A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α

The integrated stress response (ISR) is regulated by kinases that phosphorylate the α subunit of translation initiation factor 2 and phosphatases that dephosphorylate it. Genetic and biochemical observations indicate that the eIF2α(P)-directed holophosphatase, a therapeutic target in diseases of pro...

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Detalles Bibliográficos
Autores principales:	Crespillo-Casado, Ana, Claes, Zander, Choy, Meng S., Peti, Wolfgang, Bollen, Mathieu, Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961032/ https://www.ncbi.nlm.nih.gov/pubmed/29618508 http://dx.doi.org/10.1074/jbc.RA118.002325

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