Cargando…
Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation
Pseudomonas aeruginosa is an opportunistic pathogen with a relatively large genome, and has been shown to routinely lose genomic fragments during environmental selection. However, the underlying molecular mechanisms that promote chromosomal deletion are still poorly understood. In a recent study, we...
Autores principales: | Shen, Mengyu, Zhang, Huidong, Shen, Wei, Zou, Zhenyu, Lu, Shuguang, Li, Gang, He, Xuesong, Agnello, Melissa, Shi, Wenyuan, Hu, Fuquan, Le, Shuai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961081/ https://www.ncbi.nlm.nih.gov/pubmed/29514250 http://dx.doi.org/10.1093/nar/gky160 |
Ejemplares similares
-
Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012) -
The sliding clamp tethers the endonuclease domain of MutL to DNA
por: Pillon, Monica C., et al.
Publicado: (2015) -
MutL binds to 3′ resected DNA ends and blocks DNA polymerase access
por: Borsellini, Alessandro, et al.
Publicado: (2022) -
Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
por: Kim, Yoori, et al.
Publicado: (2019) -
The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)