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Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014

BACKGROUND: Brucellosis causes substantial morbidity among humans and their livestock. There are few robust estimates of the incidence of brucellosis in sub-Saharan Africa. Using cases identified through sentinel hospital surveillance and health care utilization data, we estimated the incidence of b...

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Autores principales: Carugati, Manuela, Biggs, Holly M, Maze, Michael J, Stoddard, Robyn A, Cash-Goldwasser, Shama, Hertz, Julian T, Halliday, Jo E B, Saganda, Wilbrod, Lwezaula, Bingileki F, Kazwala, Rudovick R, Cleaveland, Sarah, Maro, Venance P, Rubach, Matthew P, Crump, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961162/
https://www.ncbi.nlm.nih.gov/pubmed/29697848
http://dx.doi.org/10.1093/trstmh/try033
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author Carugati, Manuela
Biggs, Holly M
Maze, Michael J
Stoddard, Robyn A
Cash-Goldwasser, Shama
Hertz, Julian T
Halliday, Jo E B
Saganda, Wilbrod
Lwezaula, Bingileki F
Kazwala, Rudovick R
Cleaveland, Sarah
Maro, Venance P
Rubach, Matthew P
Crump, John A
author_facet Carugati, Manuela
Biggs, Holly M
Maze, Michael J
Stoddard, Robyn A
Cash-Goldwasser, Shama
Hertz, Julian T
Halliday, Jo E B
Saganda, Wilbrod
Lwezaula, Bingileki F
Kazwala, Rudovick R
Cleaveland, Sarah
Maro, Venance P
Rubach, Matthew P
Crump, John A
author_sort Carugati, Manuela
collection PubMed
description BACKGROUND: Brucellosis causes substantial morbidity among humans and their livestock. There are few robust estimates of the incidence of brucellosis in sub-Saharan Africa. Using cases identified through sentinel hospital surveillance and health care utilization data, we estimated the incidence of brucellosis in Moshi Urban and Moshi Rural Districts, Kilimanjaro Region, Tanzania, for the periods 2007–2008 and 2012–2014. METHODS: Cases were identified among febrile patients at two sentinel hospitals and were defined as having either a 4-fold increase in Brucella microscopic agglutination test titres between acute and convalescent serum or a blood culture positive for Brucella spp. Findings from a health care utilization survey were used to estimate multipliers to account for cases not seen at sentinel hospitals. RESULTS: Of 585 patients enrolled in the period 2007–2008, 13 (2.2%) had brucellosis. Among 1095 patients enrolled in the period 2012–2014, 32 (2.9%) had brucellosis. We estimated an incidence (range based on sensitivity analysis) of brucellosis of 35 (range 32–93) cases per 100 000 persons annually in the period 2007–2008 and 33 (range 30–89) cases per 100 000 persons annually in the period 2012–2014. CONCLUSIONS: We found a moderate incidence of brucellosis in northern Tanzania, suggesting that the disease is endemic and an important human health problem in this area.
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spelling pubmed-59611622018-06-06 Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014 Carugati, Manuela Biggs, Holly M Maze, Michael J Stoddard, Robyn A Cash-Goldwasser, Shama Hertz, Julian T Halliday, Jo E B Saganda, Wilbrod Lwezaula, Bingileki F Kazwala, Rudovick R Cleaveland, Sarah Maro, Venance P Rubach, Matthew P Crump, John A Trans R Soc Trop Med Hyg Original Articles BACKGROUND: Brucellosis causes substantial morbidity among humans and their livestock. There are few robust estimates of the incidence of brucellosis in sub-Saharan Africa. Using cases identified through sentinel hospital surveillance and health care utilization data, we estimated the incidence of brucellosis in Moshi Urban and Moshi Rural Districts, Kilimanjaro Region, Tanzania, for the periods 2007–2008 and 2012–2014. METHODS: Cases were identified among febrile patients at two sentinel hospitals and were defined as having either a 4-fold increase in Brucella microscopic agglutination test titres between acute and convalescent serum or a blood culture positive for Brucella spp. Findings from a health care utilization survey were used to estimate multipliers to account for cases not seen at sentinel hospitals. RESULTS: Of 585 patients enrolled in the period 2007–2008, 13 (2.2%) had brucellosis. Among 1095 patients enrolled in the period 2012–2014, 32 (2.9%) had brucellosis. We estimated an incidence (range based on sensitivity analysis) of brucellosis of 35 (range 32–93) cases per 100 000 persons annually in the period 2007–2008 and 33 (range 30–89) cases per 100 000 persons annually in the period 2012–2014. CONCLUSIONS: We found a moderate incidence of brucellosis in northern Tanzania, suggesting that the disease is endemic and an important human health problem in this area. Oxford University Press 2018-03 2018-04-25 /pmc/articles/PMC5961162/ /pubmed/29697848 http://dx.doi.org/10.1093/trstmh/try033 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Carugati, Manuela
Biggs, Holly M
Maze, Michael J
Stoddard, Robyn A
Cash-Goldwasser, Shama
Hertz, Julian T
Halliday, Jo E B
Saganda, Wilbrod
Lwezaula, Bingileki F
Kazwala, Rudovick R
Cleaveland, Sarah
Maro, Venance P
Rubach, Matthew P
Crump, John A
Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title_full Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title_fullStr Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title_full_unstemmed Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title_short Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014
title_sort incidence of human brucellosis in the kilimanjaro region of tanzania in the periods 2007–2008 and 2012–2014
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961162/
https://www.ncbi.nlm.nih.gov/pubmed/29697848
http://dx.doi.org/10.1093/trstmh/try033
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