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Multiple RPAs make WRN syndrome protein a superhelicase

RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use single-molecule FRET and magnetic tweezers to investigate the helicase activity of WRN and its stimulation by RPA. We show that WRN alone is a weak helicase...

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Detalles Bibliográficos
Autores principales:	Lee, Mina, Shin, Soochul, Uhm, Heesoo, Hong, Heesun, Kirk, Jaewon, Hyun, Kwangbeom, Kulikowicz, Tomasz, Kim, Jaehoon, Ahn, Byungchan, Bohr, Vilhelm A, Hohng, Sungchul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961295/ https://www.ncbi.nlm.nih.gov/pubmed/29668972 http://dx.doi.org/10.1093/nar/gky272

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