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Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
Prior to the onset of type 1 diabetes, there is progressive loss of immune self-tolerance, evidenced by the accumulation of islet autoantibodies and emergence of autoreactive T cells. Continued autoimmune activity leads to the destruction of pancreatic β-cells and loss of insulin secretion. Studies...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Diabetes Association
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961411/ https://www.ncbi.nlm.nih.gov/pubmed/29784651 http://dx.doi.org/10.2337/dbi17-0030 |