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Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report
AIM: To compare efficacy and safety of anticoagulants apixaban and rivaroxaban after lumbar spine surgery retrospectively. METHODS: In this study comprising 480 patients, lower-limb swelling, deep venous thrombosis, pulmonary embolism, blood loss, ecchymosis and D-dimer changes were observed. RESULT...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961446/ https://www.ncbi.nlm.nih.gov/pubmed/29796300 http://dx.doi.org/10.4155/fsoa-2017-0123 |
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author | Zhang, Kun Zhao, Shenghao Kan, Wusheng Xiao, Jun Pu, Feifei Li, Kun |
author_facet | Zhang, Kun Zhao, Shenghao Kan, Wusheng Xiao, Jun Pu, Feifei Li, Kun |
author_sort | Zhang, Kun |
collection | PubMed |
description | AIM: To compare efficacy and safety of anticoagulants apixaban and rivaroxaban after lumbar spine surgery retrospectively. METHODS: In this study comprising 480 patients, lower-limb swelling, deep venous thrombosis, pulmonary embolism, blood loss, ecchymosis and D-dimer changes were observed. RESULTS: The changes in perimeter of the legs were tested, and significant differences were noted 10 cm above the patella, but no significant differences 10 cm below the patella. Twelve thrombotic events occurred in the apixaban group and nine in rivaroxaban group. No significant difference in the incidences of thromboembolic events (p = 1.00). Compared with rivaroxaban, there was significantly less bleeding in the apixaban group (p = 0.03). CONCLUSION: Apixaban and rivaroxaban were equally effective anticoagulation therapies that exhibited similar preventive effects against postoperative venous thromboembolism after lumbar spine surgery. |
format | Online Article Text |
id | pubmed-5961446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59614462018-05-24 Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report Zhang, Kun Zhao, Shenghao Kan, Wusheng Xiao, Jun Pu, Feifei Li, Kun Future Sci OA Case Series AIM: To compare efficacy and safety of anticoagulants apixaban and rivaroxaban after lumbar spine surgery retrospectively. METHODS: In this study comprising 480 patients, lower-limb swelling, deep venous thrombosis, pulmonary embolism, blood loss, ecchymosis and D-dimer changes were observed. RESULTS: The changes in perimeter of the legs were tested, and significant differences were noted 10 cm above the patella, but no significant differences 10 cm below the patella. Twelve thrombotic events occurred in the apixaban group and nine in rivaroxaban group. No significant difference in the incidences of thromboembolic events (p = 1.00). Compared with rivaroxaban, there was significantly less bleeding in the apixaban group (p = 0.03). CONCLUSION: Apixaban and rivaroxaban were equally effective anticoagulation therapies that exhibited similar preventive effects against postoperative venous thromboembolism after lumbar spine surgery. Future Science Ltd 2018-03-14 /pmc/articles/PMC5961446/ /pubmed/29796300 http://dx.doi.org/10.4155/fsoa-2017-0123 Text en © 2018 Kun Li This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Case Series Zhang, Kun Zhao, Shenghao Kan, Wusheng Xiao, Jun Pu, Feifei Li, Kun Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title | Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title_full | Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title_fullStr | Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title_full_unstemmed | Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title_short | Comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
title_sort | comparison of apixaban and rivaroxaban for anticoagulant effect after lumbar spine surgery: a single-center report |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961446/ https://www.ncbi.nlm.nih.gov/pubmed/29796300 http://dx.doi.org/10.4155/fsoa-2017-0123 |
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