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A review of vagus nerve stimulation as a therapeutic intervention
In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961632/ https://www.ncbi.nlm.nih.gov/pubmed/29844694 http://dx.doi.org/10.2147/JIR.S163248 |
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author | Johnson, Rhaya L Wilson, Christopher G |
author_facet | Johnson, Rhaya L Wilson, Christopher G |
author_sort | Johnson, Rhaya L |
collection | PubMed |
description | In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders. Although the signaling pathway and mechanism by which VNS affects inflammation remain unknown, VNS has shown promising results in treating chronic inflammatory disorders such as sepsis, lung injury, rheumatoid arthritis (RA), and diabetes. It is also being used to control pain in fibromyalgia and migraines. This new preclinical research shows that VNS bears the promise of being applied to a wider range of therapeutic applications. |
format | Online Article Text |
id | pubmed-5961632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59616322018-05-29 A review of vagus nerve stimulation as a therapeutic intervention Johnson, Rhaya L Wilson, Christopher G J Inflamm Res Review In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders. Although the signaling pathway and mechanism by which VNS affects inflammation remain unknown, VNS has shown promising results in treating chronic inflammatory disorders such as sepsis, lung injury, rheumatoid arthritis (RA), and diabetes. It is also being used to control pain in fibromyalgia and migraines. This new preclinical research shows that VNS bears the promise of being applied to a wider range of therapeutic applications. Dove Medical Press 2018-05-16 /pmc/articles/PMC5961632/ /pubmed/29844694 http://dx.doi.org/10.2147/JIR.S163248 Text en © 2018 Johnson and Wilson. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Johnson, Rhaya L Wilson, Christopher G A review of vagus nerve stimulation as a therapeutic intervention |
title | A review of vagus nerve stimulation as a therapeutic intervention |
title_full | A review of vagus nerve stimulation as a therapeutic intervention |
title_fullStr | A review of vagus nerve stimulation as a therapeutic intervention |
title_full_unstemmed | A review of vagus nerve stimulation as a therapeutic intervention |
title_short | A review of vagus nerve stimulation as a therapeutic intervention |
title_sort | review of vagus nerve stimulation as a therapeutic intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961632/ https://www.ncbi.nlm.nih.gov/pubmed/29844694 http://dx.doi.org/10.2147/JIR.S163248 |
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