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Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer

BACKGROUND: Lung cancer is the most common type of cancer throughout the world, and the morbidity of lung cancer is continuously increasing. Patients with advanced lung cancer often cannot tolerate chemoradiotherapy. The decrease of the expression of miRNA-21 can be used as an indicator of the thera...

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Autores principales: Wu, Yue, Zhang, Jianbin, Hong, Yupeng, Wang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962241/
https://www.ncbi.nlm.nih.gov/pubmed/29735968
http://dx.doi.org/10.12659/MSM.909719
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author Wu, Yue
Zhang, Jianbin
Hong, Yupeng
Wang, Xiao
author_facet Wu, Yue
Zhang, Jianbin
Hong, Yupeng
Wang, Xiao
author_sort Wu, Yue
collection PubMed
description BACKGROUND: Lung cancer is the most common type of cancer throughout the world, and the morbidity of lung cancer is continuously increasing. Patients with advanced lung cancer often cannot tolerate chemoradiotherapy. The decrease of the expression of miRNA-21 can be used as an indicator of the therapeutic effect of lung cancer. In this study, the effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was investigated, providing reliable and important evidences. MATERIAL/METHODS: From March 2016 to March 2017, 120 patients with advanced lung cancer were examined; we collected detailed information and serum samples. The patients were treated by intravenous drip of Kanglaite, which was provided by Zhejiang Kanglaite Pharmaceutical Co., Ltd., China. We administered 200 ml intravenous drip once per day for a total of 21 days. Serum samples were collected from patients after treatments. In this study, 4 observation indexes were considered – KPS (Karnofsky performance score, KPS), body weight, adverse effects, and miRNA-21 level – evaluated before and after the Kanglaite treatment. RESULTS: Among 120 patients with advanced lung cancer, the KPS of 75 patients (63.1%) was increased after the treatment, and body weight was increased by 55.9%. In addition, serum miRNA-21 level after the Kanglaite treatment was 2.45±0.15, which was significantly lower than before treatment (3.87±0.54), (P<0.05). CONCLUSIONS: The effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was shown to significantly reduce the expression of miRNA-21, providing objective evidence for the effect of Kanglaite injection in patients with advanced lung cancer.
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spelling pubmed-59622412018-05-29 Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer Wu, Yue Zhang, Jianbin Hong, Yupeng Wang, Xiao Med Sci Monit Clinical Research BACKGROUND: Lung cancer is the most common type of cancer throughout the world, and the morbidity of lung cancer is continuously increasing. Patients with advanced lung cancer often cannot tolerate chemoradiotherapy. The decrease of the expression of miRNA-21 can be used as an indicator of the therapeutic effect of lung cancer. In this study, the effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was investigated, providing reliable and important evidences. MATERIAL/METHODS: From March 2016 to March 2017, 120 patients with advanced lung cancer were examined; we collected detailed information and serum samples. The patients were treated by intravenous drip of Kanglaite, which was provided by Zhejiang Kanglaite Pharmaceutical Co., Ltd., China. We administered 200 ml intravenous drip once per day for a total of 21 days. Serum samples were collected from patients after treatments. In this study, 4 observation indexes were considered – KPS (Karnofsky performance score, KPS), body weight, adverse effects, and miRNA-21 level – evaluated before and after the Kanglaite treatment. RESULTS: Among 120 patients with advanced lung cancer, the KPS of 75 patients (63.1%) was increased after the treatment, and body weight was increased by 55.9%. In addition, serum miRNA-21 level after the Kanglaite treatment was 2.45±0.15, which was significantly lower than before treatment (3.87±0.54), (P<0.05). CONCLUSIONS: The effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was shown to significantly reduce the expression of miRNA-21, providing objective evidence for the effect of Kanglaite injection in patients with advanced lung cancer. International Scientific Literature, Inc. 2018-05-08 /pmc/articles/PMC5962241/ /pubmed/29735968 http://dx.doi.org/10.12659/MSM.909719 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Wu, Yue
Zhang, Jianbin
Hong, Yupeng
Wang, Xiao
Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title_full Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title_fullStr Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title_full_unstemmed Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title_short Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
title_sort effects of kanglaite injection on serum mirna-21 in patients with advanced lung cancer
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962241/
https://www.ncbi.nlm.nih.gov/pubmed/29735968
http://dx.doi.org/10.12659/MSM.909719
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