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Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein
The adenosine A(2A) receptor (A(2A)R) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein G(S). Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A(2A)R at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineere...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962338/ https://www.ncbi.nlm.nih.gov/pubmed/29726815 http://dx.doi.org/10.7554/eLife.35946 |