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Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein

The adenosine A(2A) receptor (A(2A)R) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein G(S). Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A(2A)R at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineere...

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Detalles Bibliográficos
Autores principales:	García-Nafría, Javier, Lee, Yang, Bai, Xiaochen, Carpenter, Byron, Tate, Christopher G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962338/ https://www.ncbi.nlm.nih.gov/pubmed/29726815 http://dx.doi.org/10.7554/eLife.35946

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