Patient-derived iPSCs show premature neural differentiation and neuron-type specific phenotypes relevant to neurodevelopment

Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAF(Q257R), the most common cause of cardiofaciocutaneous syndrome (CFC), in an induced pluripotent stem...

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Detalles Bibliográficos
Autores principales: Yeh, Erika, Dao, Dang Q., Wu, Zhi Y., Kandalam, Santoshi M., Camacho, Federico M., Tom, Curtis, Zhang, Wandong, Krencik, Robert, Rauen, Katherine A., Ullian, Erik M., Weiss, Lauren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962360/
https://www.ncbi.nlm.nih.gov/pubmed/29158583
http://dx.doi.org/10.1038/mp.2017.238

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