Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes

The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites that cause lethal human and animal diseases. They...

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Detalles Bibliográficos
Autores principales: Rico, Eva, Jeacock, Laura, Kovářová, Julie, Horn, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962531/
https://www.ncbi.nlm.nih.gov/pubmed/29785042
http://dx.doi.org/10.1038/s41598-018-26303-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962531/
https://www.ncbi.nlm.nih.gov/pubmed/29785042
http://dx.doi.org/10.1038/s41598-018-26303-w

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