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Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes
The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites that cause lethal human and animal diseases. They...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962531/ https://www.ncbi.nlm.nih.gov/pubmed/29785042 http://dx.doi.org/10.1038/s41598-018-26303-w |