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Origin of the retroviruses: when, where, and how?

Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However...

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Detalles Bibliográficos
Autor principal: Hayward, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962544/
https://www.ncbi.nlm.nih.gov/pubmed/28672160
http://dx.doi.org/10.1016/j.coviro.2017.06.006
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author Hayward, Alexander
author_facet Hayward, Alexander
author_sort Hayward, Alexander
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description Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genomics and bioinformatics have opened the way for great strides in understanding. Recent research employing a wide variety of bioinformatic approaches has demonstrated that retroviruses evolved during the early Palaeozoic Era, between 460 and 550 million years ago, providing the oldest inferred date estimate for any virus group. This finding presents an important framework to investigate the evolutionary transitions that led to the emergence of the retroviruses, offering potential insights into the infectious origins of a major group of pathogenic viruses.
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spelling pubmed-59625442018-05-30 Origin of the retroviruses: when, where, and how? Hayward, Alexander Curr Opin Virol Article Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genomics and bioinformatics have opened the way for great strides in understanding. Recent research employing a wide variety of bioinformatic approaches has demonstrated that retroviruses evolved during the early Palaeozoic Era, between 460 and 550 million years ago, providing the oldest inferred date estimate for any virus group. This finding presents an important framework to investigate the evolutionary transitions that led to the emergence of the retroviruses, offering potential insights into the infectious origins of a major group of pathogenic viruses. Elsevier 2017-08 /pmc/articles/PMC5962544/ /pubmed/28672160 http://dx.doi.org/10.1016/j.coviro.2017.06.006 Text en © 2017 The Author http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hayward, Alexander
Origin of the retroviruses: when, where, and how?
title Origin of the retroviruses: when, where, and how?
title_full Origin of the retroviruses: when, where, and how?
title_fullStr Origin of the retroviruses: when, where, and how?
title_full_unstemmed Origin of the retroviruses: when, where, and how?
title_short Origin of the retroviruses: when, where, and how?
title_sort origin of the retroviruses: when, where, and how?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962544/
https://www.ncbi.nlm.nih.gov/pubmed/28672160
http://dx.doi.org/10.1016/j.coviro.2017.06.006
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