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Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor

Dihydrodipicolinate reductase (DHDPR) is a key enzyme in the diaminopimelate- and lysine-synthesis pathways that reduces DHDP to tetrahydrodipicolinate. Although DHDPR uses both NADPH and NADH as a cofactor, the structural basis for cofactor specificity and preference remains unclear. Here, we repor...

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Detalles Bibliográficos
Autores principales:	Lee, Chang Woo, Park, Sun-Ha, Lee, Sung Gu, Park, Hyun Ho, Kim, Hak Jun, Park, HaJeung, Park, Hyun, Lee, Jun Hyuck
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962572/ https://www.ncbi.nlm.nih.gov/pubmed/29786696 http://dx.doi.org/10.1038/s41598-018-26291-x

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