Cargando…

Human-relevant potency threshold (HRPT) for ERα agonism

The European Commission has recently proposed draft criteria for the identification of endocrine disrupting chemicals (EDCs) that pose a significant hazard to humans or the environment. Identifying and characterizing toxic hazards based on the manner by which adverse effects are produced rather than...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borgert, Christopher J., Matthews, John C., Baker, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Molecular Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962616/ https://www.ncbi.nlm.nih.gov/pubmed/29632997 http://dx.doi.org/10.1007/s00204-018-2186-z

Ejemplares similares

Derivation of New Threshold of Toxicological Concern Values for Exposure via Inhalation for Environmentally-Relevant Chemicals
por: Nelms, Mark D., et al.
Publicado: (2020)

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
por: Loser, Dominik, et al.
Publicado: (2021)

Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells
por: Covaleda, Ana M. Sotoca, et al.
Publicado: (2008)

Activation of autophagy triggers mitochondrial loss and changes acetylation profile relevant for mechanotransduction in bladder cancer cells
por: Jobst, Maximilian, et al.
Publicado: (2022)

Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression
por: Caiment, F., et al.
Publicado: (2020)

Ecological Thresholds of Toxicological Concern: A Review
por: Barron, Mace G., et al.
Publicado: (2021)

Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
por: Batke, Monika, et al.
Publicado: (2021)

Editorial: Advances and Refinements in the Development and Application of Threshold of Toxicological Concern
por: Patlewicz, Grace, et al.
Publicado: (2022)

Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety
por: Borgert, C. J., et al.
Publicado: (2021)

On-Site Deployment of an Air-Liquid-Interphase Device to Assess Health Hazard Potency of Airborne Workplace Contaminants: The Case of 3-D Printers
por: Kim, Boowook, et al.
Publicado: (2022)

Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities
por: Serafimova, Rositsa, et al.
Publicado: (2021)

Roles of cytosolic phospholipase A(2)α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice
por: Fujisawa, Nozomi, et al.
Publicado: (2017)

Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
por: Müller-Dott, Katharina, et al.
Publicado: (2022)

Editorial: Chemical allergy and the relevance of new models
por: Pallardy, Marc, et al.
Publicado: (2023)

Long-term AZT Exposure Alters the Metabolic Capacity of Cultured Human Lymphoblastoid Cells
por: Olivero, Ofelia A., et al.
Publicado: (2010)

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2
por: Mundy, Paige C., et al.
Publicado: (2023)

Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future
por: Ellison, Corie A., et al.
Publicado: (2021)

Development of a New Threshold of Toxicological Concern Database of Non-cancer Toxicity Endpoints for Industrial Chemicals
por: Yamada, Takashi, et al.
Publicado: (2021)

Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells
por: Janssen, Aafke W. F., et al.
Publicado: (2022)

PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cells
por: Pierozan, Paula, et al.
Publicado: (2017)

Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells
por: Pierozan, Paula, et al.
Publicado: (2018)

Deoxynivalenol induces apoptosis and autophagy in human prostate epithelial cells via PI3K/Akt signaling pathway
por: Kowalska, Karolina, et al.
Publicado: (2021)

The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro
por: Haasler, Lisa, et al.
Publicado: (2021)

TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts
por: Zeitlmayr, Sarah, et al.
Publicado: (2022)

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
por: Martin, Tobias, et al.
Publicado: (2017)

Development of the SciRAP Approach for Evaluating the Reliability and Relevance of in vitro Toxicity Data
por: Roth, Nicolas, et al.
Publicado: (2021)

Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines
por: Hsieh, Ming-Ju, et al.
Publicado: (2013)

Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells
por: Louisse, Jochem, et al.
Publicado: (2020)

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta
por: Granitzer, Sebastian, et al.
Publicado: (2020)

2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity
por: Watson, John D., et al.
Publicado: (2016)

Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro
por: Steinritz, Dirk, et al.
Publicado: (2021)

Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria
por: Nisar, R., et al.
Publicado: (2015)

Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action
por: Labib, S., et al.
Publicado: (2015)

Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium
por: Probst, Stephanie, et al.
Publicado: (2021)

In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals
por: Matteo, Geronimo, et al.
Publicado: (2022)

Biochemical characteristics of point mutated Capra hircus lysosome α-mannosidase
por: WANG, Yan, et al.
Publicado: (2023)

The Glutaredoxin GLRX-21 Functions to Prevent Selenium-Induced Oxidative Stress in Caenorhabditis elegans
por: Morgan, Kathleen L., et al.
Publicado: (2010)

Effects of Perfluoroalkyl Compounds on mRNA Expression Levels of Thyroid Hormone-Responsive Genes in Primary Cultures of Avian Neuronal Cells
por: Vongphachan, Viengtha, et al.
Publicado: (2011)

Chloramphenicol Causes Mitochondrial Stress, Decreases ATP Biosynthesis, Induces Matrix Metalloproteinase-13 Expression, and Solid-Tumor Cell Invasion
por: Li, Ching-Hao, et al.
Publicado: (2010)

The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis
por: Rahden-Staroń, I., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_12lapnfe3bajgo0rdkmue34qas