Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice

Histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (HDAC) inhibitor sodium butyrate (NaB) has been demonstrated to improve memory performance and rescue the neurodegeneration of several Alzheimer’s Disease (AD) mouse models. The forebrain presenili...

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Detalles Bibliográficos
Autores principales: Cao, Ting, Zhou, Xiaojuan, Zheng, Xianjie, Cui, Yue, Tsien, Joe Z., Li, Chunxia, Wang, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962686/
https://www.ncbi.nlm.nih.gov/pubmed/29867447
http://dx.doi.org/10.3389/fnagi.2018.00137

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