Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report

The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal sy...

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Detalles Bibliográficos
Autores principales: Gil-Perotin, Sara, Castillo-Villalba, Jéssica, Carreres-Polo, Joan, Navarré-Gimeno, Arantxa, Mallada-Frechín, Javier, Pérez-Miralles, Francisco, Gascón, Francisco, Alcalá-Vicente, Carmen, Cubas-Nuñez, Laura, Casanova-Estruch, Bonaventura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962713/
https://www.ncbi.nlm.nih.gov/pubmed/29867746
http://dx.doi.org/10.3389/fneur.2018.00340
Descripción
Sumario:The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes [in the neuromyelitis optica spectrum disorders (NMOSD) and less frequently, in multiple sclerosis (MS)], but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG.

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