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Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report
The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal sy...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962713/ https://www.ncbi.nlm.nih.gov/pubmed/29867746 http://dx.doi.org/10.3389/fneur.2018.00340 |
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author | Gil-Perotin, Sara Castillo-Villalba, Jéssica Carreres-Polo, Joan Navarré-Gimeno, Arantxa Mallada-Frechín, Javier Pérez-Miralles, Francisco Gascón, Francisco Alcalá-Vicente, Carmen Cubas-Nuñez, Laura Casanova-Estruch, Bonaventura |
author_facet | Gil-Perotin, Sara Castillo-Villalba, Jéssica Carreres-Polo, Joan Navarré-Gimeno, Arantxa Mallada-Frechín, Javier Pérez-Miralles, Francisco Gascón, Francisco Alcalá-Vicente, Carmen Cubas-Nuñez, Laura Casanova-Estruch, Bonaventura |
author_sort | Gil-Perotin, Sara |
collection | PubMed |
description | The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes [in the neuromyelitis optica spectrum disorders (NMOSD) and less frequently, in multiple sclerosis (MS)], but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG. |
format | Online Article Text |
id | pubmed-5962713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59627132018-06-04 Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report Gil-Perotin, Sara Castillo-Villalba, Jéssica Carreres-Polo, Joan Navarré-Gimeno, Arantxa Mallada-Frechín, Javier Pérez-Miralles, Francisco Gascón, Francisco Alcalá-Vicente, Carmen Cubas-Nuñez, Laura Casanova-Estruch, Bonaventura Front Neurol Neuroscience The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes [in the neuromyelitis optica spectrum disorders (NMOSD) and less frequently, in multiple sclerosis (MS)], but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG. Frontiers Media S.A. 2018-05-15 /pmc/articles/PMC5962713/ /pubmed/29867746 http://dx.doi.org/10.3389/fneur.2018.00340 Text en Copyright © 2018 Gil-Perotin, Castillo-Villalba, Carreres-Polo, Navarré-Gimeno, Mallada-Frechín, Pérez-Miralles, Gascón, Alcalá-Vicente, Cubas-Nuñez and Casanova-Estruch. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Gil-Perotin, Sara Castillo-Villalba, Jéssica Carreres-Polo, Joan Navarré-Gimeno, Arantxa Mallada-Frechín, Javier Pérez-Miralles, Francisco Gascón, Francisco Alcalá-Vicente, Carmen Cubas-Nuñez, Laura Casanova-Estruch, Bonaventura Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title | Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title_full | Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title_fullStr | Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title_full_unstemmed | Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title_short | Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report |
title_sort | progressive demyelination in the presence of serum myelin oligodendrocyte glycoprotein-igg: a case report |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962713/ https://www.ncbi.nlm.nih.gov/pubmed/29867746 http://dx.doi.org/10.3389/fneur.2018.00340 |
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