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Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations

When a small molecule binds to the androgen receptor (AR), a conformational change can occur which impacts subsequent binding of co-regulator proteins and DNA. In order to accurately study this mechanism, the scientific community needs a crystal structure of the Wild type AR (WT-AR) ligand binding d...

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Detalles Bibliográficos
Autores principales:	Sakkiah, Sugunadevi, Kusko, Rebecca, Pan, Bohu, Guo, Wenjing, Ge, Weigong, Tong, Weida, Hong, Huixiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962723/ https://www.ncbi.nlm.nih.gov/pubmed/29867496 http://dx.doi.org/10.3389/fphar.2018.00492

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