Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand ho...

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Detalles Bibliográficos
Autores principales: Fazakas, Csilla, Nagaraj, Chandran, Zabini, Diana, Végh, Attila G., Marsh, Leigh M., Wilhelm, Imola, Krizbai, István A., Olschewski, Horst, Olschewski, Andrea, Bálint, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962749/
https://www.ncbi.nlm.nih.gov/pubmed/29867576
http://dx.doi.org/10.3389/fphys.2018.00537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962749/
https://www.ncbi.nlm.nih.gov/pubmed/29867576
http://dx.doi.org/10.3389/fphys.2018.00537

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