NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin

The pathophysiology of body weight gain that is observed in patients suffering from myeloproliferative neoplasms treated with inhibitors of the janus kinase (Jak) 1 and 2 pathway remains unknown. Here we hypothesized that this class of drugs interferes with the metabolic actions of leptin, as this h...

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Detalles Bibliográficos
Autores principales: Haissaguerre, Magalie, Ferriere, Amandine, Clark, Samantha, Guzman-Quevedo, Omar, Tabarin, Antoine, Cota, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962752/
https://www.ncbi.nlm.nih.gov/pubmed/29867515
http://dx.doi.org/10.3389/fphar.2018.00527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962752/
https://www.ncbi.nlm.nih.gov/pubmed/29867515
http://dx.doi.org/10.3389/fphar.2018.00527

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