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Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in...

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Detalles Bibliográficos
Autores principales:	He, Xiao-Tao, Zhou, Kai-Xiang, Zhao, Wen-Jun, Zhang, Chen, Deng, Jian-Ping, Chen, Fa-Ming, Gu, Ze-Xu, Li, Yun-Qing, Dong, Yu-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962808/ https://www.ncbi.nlm.nih.gov/pubmed/29867508 http://dx.doi.org/10.3389/fphar.2018.00509

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