Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review

BACKGROUND: Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is used to screen for Lynch syndrome in endomet...

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Detalles Bibliográficos
Autores principales: Yokoyama, Takanori, Takehara, Kazuhiro, Sugimoto, Nao, Kaneko, Keika, Fujimoto, Etsuko, Okazawa-Sakai, Mika, Okame, Shinichi, Shiroyama, Yuko, Yokoyama, Takashi, Teramoto, Norihiro, Ohsumi, Shozo, Saito, Shinya, Imai, Kazuho, Sugano, Kokichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963021/
https://www.ncbi.nlm.nih.gov/pubmed/29783979
http://dx.doi.org/10.1186/s12885-018-4489-0

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