Cargando…

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, including gefitinib, are first-line drugs against advanced non-small cell lung cancer with activating EGFR mutations. However, the development of resistance to such drugs is a major clinical challenge. METHODS: The role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jian, Chang, Meijia, Li, Jing, Fang, Tao, Hu, Jie, Bai, Chunxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963077/ https://www.ncbi.nlm.nih.gov/pubmed/29784046 http://dx.doi.org/10.1186/s12931-018-0804-1

Ejemplares similares

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling
por: Zhang, Ge, et al.
Publicado: (2018)

Knockdown of PLAT enhances the anticancer effect of gefitinib in non-small cell lung cancer
por: Yan, Mengnan, et al.
Publicado: (2020)

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)

Knockdown of Annexin A2 Enhances Radiosensitivity by Increasing G2/M-Phase Arrest, Apoptosis and Activating the p38 MAPK-HSP27 Pathway in Nasopharyngeal Carcinoma
por: He, Huocong, et al.
Publicado: (2022)

Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
por: Rattanapornsompong, Khanti, et al.
Publicado: (2021)

Annexin A3 Knockdown Suppresses Lung Adenocarcinoma
por: Liu, Ying-Fu, et al.
Publicado: (2016)

TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy
por: Zhu, Hongyuan, et al.
Publicado: (2020)

G2/M cell cycle arrest in the life cycle of viruses
por: Davy, Clare, et al.
Publicado: (2007)

Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells
por: Wang, Qing-Qing, et al.
Publicado: (2011)

Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem Cells
por: Pitrone, Maria, et al.
Publicado: (2019)

Knockdown of Regulator of Cullins-1 (ROC1) Expression Induces Bladder Cancer Cell Cycle Arrest at the G2 Phase and Senescence
por: Wang, Wei, et al.
Publicado: (2013)

Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma
por: Liao, Li, et al.
Publicado: (2018)

HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis
por: Chile, Thais, et al.
Publicado: (2013)

Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
por: Guo, Hongrui, et al.
Publicado: (2015)

Hinokitiol Induces DNA Damage and Autophagy followed by Cell Cycle Arrest and Senescence in Gefitinib-Resistant Lung Adenocarcinoma Cells
por: Li, Lan-Hui, et al.
Publicado: (2014)

REG γ knockdown suppresses proliferation by inducing apoptosis and cell cycle arrest in osteosarcoma
por: Yin, Zhiqiang, et al.
Publicado: (2020)

Novel betulin derivative induces anti-proliferative activity by G(2)/M phase cell cycle arrest and apoptosis in Huh7 cells
por: Zhuo, Zhen-Jian, et al.
Publicado: (2018)

TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis
por: Huang, Yongjiu, et al.
Publicado: (2020)

The molecular mechanism of G(2)/M cell cycle arrest induced by AFB(1) in the jejunum
por: Yin, Heng, et al.
Publicado: (2016)

Radiosensitizing effects of c-myc gene knockdown-induced G2/M phase arrest by intrinsic stimuli via the mitochondrial signaling pathway
por: Fan, Yunpeng, et al.
Publicado: (2020)

Knockdown of DLGAP5 suppresses cell proliferation, induces G(2)/M phase arrest and apoptosis in ovarian cancer
por: Zhang, Huijun, et al.
Publicado: (2021)

Knockdown of lncRNA AL928768.3 inhibits multiple myeloma cell proliferation by inducing cell cycle arrest in G0/G1 phase
por: Shen, Qian, et al.
Publicado: (2022)

The restorative role of annexin A1 at the blood–brain barrier
por: McArthur, Simon, et al.
Publicado: (2016)

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
por: Noguchi, Masafumi, et al.
Publicado: (2023)

T. gondii RP Promoters & Knockdown Reveal Molecular Pathways Associated with Proliferation and Cell-Cycle Arrest
por: Hutson, Samuel L., et al.
Publicado: (2010)

Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis
por: Hao, Chunyan, et al.
Publicado: (2018)

EDIL3 knockdown inhibits retinal angiogenesis through the induction of cell cycle arrest in vitro
por: Shen, Wei, et al.
Publicado: (2017)

Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells
por: Lv, Xiuhe, et al.
Publicado: (2019)

CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
por: Zhou, Yan, et al.
Publicado: (2021)

Cell Cycle Arrest by a Natural Product via G2/M Checkpoint
por: Luk, Sharon Chui-Wah, et al.
Publicado: (2005)

Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis
por: Guo, Jian, et al.
Publicado: (2019)

Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest
por: Duangmano, Suwit, et al.
Publicado: (2012)

Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response
por: Guo, Hongrui, et al.
Publicado: (2016)

Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway
por: Song, Yong-An, et al.
Publicado: (2019)

NICE-3-knockdown induces cell cycle arrest and autophagy in lung adenocarcinoma cells via the AKT/mTORC1 signaling pathway
por: Du, Longxia, et al.
Publicado: (2021)

Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis
por: Zhou, Xumin, et al.
Publicado: (2018)

Corrigendum to “Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest”
por: Duangmano, Suwit, et al.
Publicado: (2015)

Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal
por: Yin, Xiteng, et al.
Publicado: (2018)

Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells
por: Song, Xiao-ling, et al.
Publicado: (2017)

Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma
por: Ding, Tianling, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r88f20qehc36dlges6gplkap1c