The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l

Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this comment describeds new data which indicate that such cut-offs are too low a...

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Autor principal: Korevaar, Tim I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963163/
https://www.ncbi.nlm.nih.gov/pubmed/29942352
http://dx.doi.org/10.1186/s13044-018-0048-7
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author Korevaar, Tim I. M.
author_facet Korevaar, Tim I. M.
author_sort Korevaar, Tim I. M.
collection PubMed
description Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this comment describeds new data which indicate that such cut-offs are too low and may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. Also a stepwise approach to interpreting these guidelines is discussed as well as the relevant role of FT4 in diagnosis.
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spelling pubmed-59631632018-06-25 The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l Korevaar, Tim I. M. Thyroid Res Commentary Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this comment describeds new data which indicate that such cut-offs are too low and may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. Also a stepwise approach to interpreting these guidelines is discussed as well as the relevant role of FT4 in diagnosis. BioMed Central 2018-05-21 /pmc/articles/PMC5963163/ /pubmed/29942352 http://dx.doi.org/10.1186/s13044-018-0048-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Korevaar, Tim I. M.
The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title_full The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title_fullStr The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title_full_unstemmed The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title_short The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mU/l
title_sort upper limit for tsh during pregnancy: why we should stop using fixed limits of 2.5 or 3.0 mu/l
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963163/
https://www.ncbi.nlm.nih.gov/pubmed/29942352
http://dx.doi.org/10.1186/s13044-018-0048-7
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