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The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma

BACKGROUND: PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to antitumor therapies. Therefore, PARP inhibition being evaluated as an anti-cancer therapy. However, there are limited studies regra...

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Detalles Bibliográficos
Autores principales:	Park, Hye Jeong, Bae, Jun Sang, Kim, Kyoung Min, Moon, Young Jae, Park, See-Hyoung, Ha, Sang Hoon, Hussein, Usama Khamis, Zhang, Zhongkai, Park, Ho Sung, Park, Byung-Hyun, Moon, Woo Sung, Kim, Jung Ryul, Jang, Kyu Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963190/ https://www.ncbi.nlm.nih.gov/pubmed/29784019 http://dx.doi.org/10.1186/s13046-018-0772-9

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