Bitopic Binding Mode of an M(1) Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

The realization of the therapeutic potential of targeting the M(1) muscarinic acetylcholine receptor (mAChR) for the treatment of cognitive decline in Alzheimer’s disease has prompted the discovery of M(1) mAChR ligands showing efficacy in alleviating cognitive dysfunction in both rodents and humans...

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Detalles Bibliográficos
Autores principales: Bradley, Sophie J., Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J., Thompson, Karen J., Dwomoh, Louis, Sanger, Helen E., Crabtree, Michael D., Brooke, Simon M., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Broad, Lisa M., Tobin, Andrew B., Langmead, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963591/
https://www.ncbi.nlm.nih.gov/pubmed/29695609
http://dx.doi.org/10.1124/mol.118.111872

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