Oridonin inhibits aberrant AKT activation in breast cancer

Aberrant activation of phosphatidylinosito-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) signaling in cancer has led to pursuit of inhibitors for targeting this pathway. However, inhibitors of PI3K and AKT have failed to yield efficacious results without adverse effects. Here, we screened a...

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Detalles Bibliográficos
Autores principales: Sun, Bowen, Wang, Geng, Liu, Huidong, Liu, Pian, Twal, Waleed O., Cheung, Hiuwing, Carroll, Steven L., Ethier, Stephen P., Mevers, Emily E., Clardy, Jon, Roberts, Thomas, Chen, Changbin, Li, Qian, Wang, Lanfeng, Yang, Meixiang, Zhao, Jean J., Wang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963618/
https://www.ncbi.nlm.nih.gov/pubmed/29844859
http://dx.doi.org/10.18632/oncotarget.24378

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